Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

Dong Wang, Ivan Garcia-Bassets (), Chris Benner, Wenbo Li, Xue Su, Yiming Zhou, Jinsong Qiu, Wen Liu, Minna U. Kaikkonen, Kenneth A. Ohgi, Christopher K. Glass, Michael G. Rosenfeld () and Xiang-Dong Fu ()
Additional contact information
Dong Wang: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Ivan Garcia-Bassets: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Chris Benner: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Wenbo Li: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Xue Su: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Yiming Zhou: Digomics LLC, PO Box 30, Malden, Massachusetts 02148, USA
Jinsong Qiu: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Wen Liu: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Minna U. Kaikkonen: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Kenneth A. Ohgi: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Christopher K. Glass: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Michael G. Rosenfeld: Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA
Xiang-Dong Fu: School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0651, USA

Nature, 2011, vol. 474, issue 7351, 390-394

Abstract: FoxA genomic surveillance mechanism Transcriptional enhancers orchestrate cell-type-specific gene expression programs, but how they convey signal-activated transcriptional responses remains poorly understood. Here, the cell-lineage-specific transcription factor FoxA1 is shown to both facilitate and restrict the androgen receptor to act on distinct classes of enhancers. Lowered levels of FoxA1, such as those found in prostate cancer, can reprogram the hormonal response by causing a switch in androgen receptor binding to a set of pre-established, functional enhancers that are marked by enhancer-derived non-coding RNAs (eRNAs). This work points to the existence of a large repository of active enhancers that can be tuned to allow alternative gene expression programs in normal cell development and in disease progression.

Date: 2011
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DOI: 10.1038/nature10006

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