Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

Leif E. Sander, Michael J. Davis, Mark V. Boekschoten, Derk Amsen, Christopher C. Dascher, Bernard Ryffel, Joel A. Swanson, Michael Müller and J. Magarian Blander ()
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Leif E. Sander: Immunology Institute, Mount Sinai School of Medicine
Michael J. Davis: University of Michigan
Mark V. Boekschoten: Nutrition, Metabolism and Genomics Group, Wageningen University
Derk Amsen: Academic Medical Center, University of Amsterdam
Christopher C. Dascher: Immunology Institute, Mount Sinai School of Medicine
Bernard Ryffel: Laboratory of Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique
Joel A. Swanson: University of Michigan
Michael Müller: Nutrition, Metabolism and Genomics Group, Wageningen University
J. Magarian Blander: Immunology Institute, Mount Sinai School of Medicine

Nature, 2011, vol. 474, issue 7351, 385-389

Abstract: Where there's life there's a PAMP The innate immune system targets PAMPs (pathogen-associated molecular patterns) — invariant molecules crucial to the composition of microbial cells but absent from host tissues — to discriminate self from non-self structures. Now, a similar mechanism has been implicated in determining the differences in the immune response to viable and dead pathogens. Sander et al. identify stimulatory messenger RNA, present in live but not dead bacteria, as a viability-associated PAMP, or vita-PAMP. By incorporating vita-PAMPs in vaccines, it might be possible to combine the efficacy of a live vaccine with the safety associated with dead vaccines.

Date: 2011
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DOI: 10.1038/nature10072

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