Converting nonsense codons into sense codons by targeted pseudouridylation

John Karijolich and Yi-Tao Yu ()
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John Karijolich: University of Rochester Medical Center
Yi-Tao Yu: University of Rochester Medical Center

Nature, 2011, vol. 474, issue 7351, 395-398

Abstract: Nonsense codons taken as read The three 'nonsense' or 'stop' codons that signal the ribosome to cease translation — UAA, UAG and UGA — all contain an initial uridine residue. John Karijolich and Yi-Tao Yu demonstrate that isomerization of this uridine, converting it to pseudouridine (Ψ), allows the codons to be read by the ribosome in vivo. Specific amino acids are inserted into the resulting protein, with ΨAA and ΨAG coding for serine and threonine, and ΨGA for tyrosine and phenylalanine. Although there is yet no evidence for a physiological role for this RNA modification, it could offer a way of expanding the genetic code. Similar RNA modification could also be useful as a means of nonsense suppression in vivo, either experimentally or clinically.

Date: 2011
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DOI: 10.1038/nature10165

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