Intestinal homeostasis and its breakdown in inflammatory bowel disease

Kevin J. Maloy () and Fiona Powrie ()
Additional contact information
Kevin J. Maloy: Sir William Dunn School of Pathology, University of Oxford
Fiona Powrie: Sir William Dunn School of Pathology, University of Oxford

Nature, 2011, vol. 474, issue 7351, 298-306

Abstract: Abstract Intestinal homeostasis depends on complex interactions between the microbiota, the intestinal epithelium and the host immune system. Diverse regulatory mechanisms cooperate to maintain intestinal homeostasis, and a breakdown in these pathways may precipitate the chronic inflammatory pathology found in inflammatory bowel disease. It is now evident that immune effector modules that drive intestinal inflammation are conserved across innate and adaptive leukocytes and can be controlled by host regulatory cells. Recent evidence suggests that several factors may tip the balance between homeostasis and intestinal inflammation, presenting future challenges for the development of new therapies for inflammatory bowel disease.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature10208 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:474:y:2011:i:7351:d:10.1038_nature10208

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10208

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().