Non-adaptive origins of interactome complexity
Ariel Fernández () and
Michael Lynch ()
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Ariel Fernández: The University of Chicago
Michael Lynch: Indiana University
Nature, 2011, vol. 474, issue 7352, 502-505
Abstract:
How proteins get the drift Sampling bias in small populations can result in a non-adaptive evolutionary phenomenon called genetic drift. By comparing the protein-coding genomes of many species, Ariel Fernández and Michael Lynch show that population-size bottlenecks allow for the appearance of mildly destabilized proteins that can subsequently be re-stabilized through new protein–protein interactions. These interactions can then evolve into meaningful biochemical pathways. Thus, although complex protein architectures and interactions may be essential contributors to phenotypic complexity, such features may initially emerge through non-adaptive mechanisms.
Date: 2011
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Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:474:y:2011:i:7352:d:10.1038_nature09992
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DOI: 10.1038/nature09992
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