Determinants of nucleosome organization in primary human cells

Anton Valouev, Steven M. Johnson, Scott D. Boyd, Cheryl L. Smith, Andrew Z. Fire () and Arend Sidow ()
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Anton Valouev: Stanford University School of Medicine, 300 Pasteur Drive
Steven M. Johnson: Brigham Young University, 757 WIDB
Scott D. Boyd: Stanford University School of Medicine, 300 Pasteur Drive
Cheryl L. Smith: Stanford University School of Medicine, 300 Pasteur Drive
Andrew Z. Fire: Stanford University School of Medicine, 300 Pasteur Drive
Arend Sidow: Stanford University School of Medicine, 300 Pasteur Drive

Nature, 2011, vol. 474, issue 7352, 516-520

Abstract: Nucleosome positions mapped The organization of nucleosomes across the genome influences gene regulation, and understanding the mechanisms that underlie this organization in different organisms is an active area of research. In this study, genome-wide maps of nucleosome positions in three primary human cell types and in vitro have been generated by high-throughput DNA sequencing. Most of the genome exhibits substantial flexibility of nucleosome positions, and a combination of intrinsic sequence-based nucleosome preferences and interactions with non-nucleosomal factors determine nucleosome organization in vivo.

Date: 2011
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DOI: 10.1038/nature10002

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