Regulation of angiogenesis by a non-canonical Wnt–Flt1 pathway in myeloid cells

James A. Stefater, Ian Lewkowich, Sujata Rao, Giovanni Mariggi, April C. Carpenter, Adam R. Burr, Jieqing Fan, Rieko Ajima, Jeffery D. Molkentin, Bart O. Williams, Marsha Wills-Karp, Jeffrey W. Pollard, Terry Yamaguchi, Napoleone Ferrara, Holger Gerhardt and Richard A. Lang ()
Additional contact information
James A. Stefater: The Visual Systems Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Ian Lewkowich: Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Sujata Rao: The Visual Systems Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Giovanni Mariggi: Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2 3PX, UK
April C. Carpenter: The Visual Systems Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Adam R. Burr: Cincinnati Children’s Hospital Medical Center, University of Cincinnati
Jieqing Fan: The Visual Systems Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Rieko Ajima: Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, Maryland 21701, USA
Jeffery D. Molkentin: Cincinnati Children’s Hospital Medical Center, University of Cincinnati
Bart O. Williams: Center for Skeletal Disease Research, Van Andel Research Institute, 333 Bostwick NE, Grand Rapids, Michigan 49503, USA
Marsha Wills-Karp: Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Jeffrey W. Pollard: Albert Einstein College of Medicine of Yeshiva University, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Terry Yamaguchi: Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, Maryland 21701, USA
Napoleone Ferrara: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Holger Gerhardt: Vascular Biology Laboratory, London Research Institute, Cancer Research UK, London WC2 3PX, UK
Richard A. Lang: The Visual Systems Group, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio 45229, USA

Nature, 2011, vol. 474, issue 7352, 511-515

Abstract: Angiogenesis regulation in the retina Richard Lang and colleagues identify a mechanism by which myeloid cells regulate the pattern of blood-vessel branching in the post-natal retina. They show that macrophages inhibit branching by secreting Wnt ligands that use a non-canonical pathway to induce secretion of the VEGF inhibitory receptor Flt1.

Date: 2011
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DOI: 10.1038/nature10085

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