Latent TGF-β binding protein 3 identifies a second heart field in zebrafish

Yong Zhou, Timothy J. Cashman, Kathleen R. Nevis, Pablo Obregon, Sara A. Carney, Yan Liu, Aihua Gu, Christian Mosimann, Samuel Sondalle, Richard E. Peterson, Warren Heideman, Caroline E. Burns () and C. Geoffrey Burns ()
Additional contact information
Yong Zhou: Cardiovascular Research Center, Massachusetts General Hospital
Timothy J. Cashman: Cardiovascular Research Center, Massachusetts General Hospital
Kathleen R. Nevis: Cardiovascular Research Center, Massachusetts General Hospital
Pablo Obregon: Cardiovascular Research Center, Massachusetts General Hospital
Sara A. Carney: School of Pharmacy, University of Wisconsin
Yan Liu: Harvard Medical School, Boston, Massachusetts 02115, USA
Aihua Gu: Cardiovascular Research Center, Massachusetts General Hospital
Christian Mosimann: Harvard Medical School, Boston, Massachusetts 02115, USA
Samuel Sondalle: Cardiovascular Research Center, Massachusetts General Hospital
Richard E. Peterson: School of Pharmacy, University of Wisconsin
Warren Heideman: School of Pharmacy, University of Wisconsin
Caroline E. Burns: Cardiovascular Research Center, Massachusetts General Hospital
C. Geoffrey Burns: Cardiovascular Research Center, Massachusetts General Hospital

Nature, 2011, vol. 474, issue 7353, 645-648

Abstract: Affairs of the embryonic heart Progenitor cells from the second heart field, which generate the right ventricle, were considered unique to higher vertebrates with four-chambered hearts. Researchers have now identified a group of cardiac progenitors that express the TGF-β signalling regulator ltbp3 that contributes late-differentiating myocytes to the ventricle and outflow tract of zebrafish. This suggests that lower vertebrates also have second-heart-field cells, which augment the function of the single ventricular chamber. The trait may have conferred an evolutionary advantage to a common ancestor of zebrafish and mammals.

Date: 2011
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DOI: 10.1038/nature10094

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