A gene regulatory network controlling the embryonic specification of endoderm

Isabelle S. Peter () and Eric H. Davidson ()
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Isabelle S. Peter: California Institute of Technology, Pasadena, California 91125, USA
Eric H. Davidson: California Institute of Technology, Pasadena, California 91125, USA

Nature, 2011, vol. 474, issue 7353, 635-639

Abstract: Dissection of a gene network As embryos develop, cells differentiate and produce new repertoires of gene regulatory proteins. Conventional studies of one or a few genes at a time do not reveal which events drive such dynamic changes. Isabelle Peter and Eric Davidson now present a functional dissection of the large gene regulatory network involved in meso-endodermic specification in the sea urchin embryo. The resulting global view reveals unexpected mechanisms for the separation of these early cell lineages and for the regional specification of later derivatives such as the various segments of the gut.

Date: 2011
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DOI: 10.1038/nature10100

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