MicroRNAs 103 and 107 regulate insulin sensitivity

Mirko Trajkovski, Jean Hausser, Jürgen Soutschek, Bal Bhat, Akinc Akin, Mihaela Zavolan, Markus H. Heim and Markus Stoffel ()
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Mirko Trajkovski: Institute for Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, CH-8093 Zurich, Switzerland
Jean Hausser: Competence Center of Systems Physiology and Metabolic Disease, ETH Zurich, Schafmattstrasse 18, HPM F 39.1 CH-8093 Zurich, Switzerland
Jürgen Soutschek: Regulus Therapeutics Inc., 3545 John Hopkins Court
Bal Bhat: Regulus Therapeutics Inc., 3545 John Hopkins Court
Akinc Akin: Alnylam Pharmaceuticals, 300 Third Street
Mihaela Zavolan: Biozentrum Basel, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland
Markus H. Heim: Competence Center of Systems Physiology and Metabolic Disease, ETH Zurich, Schafmattstrasse 18, HPM F 39.1 CH-8093 Zurich, Switzerland
Markus Stoffel: Institute for Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli Strasse 16, CH-8093 Zurich, Switzerland

Nature, 2011, vol. 474, issue 7353, 649-653

Abstract: A new target for diabetes and obesity drugs A microRNA (miRNA) microarray analysis of the livers of two mouse models of obesity show that the expression of miRNA-103 and miRNA-107 is upregulated in obesity. Silencing these miRNAs improves glucose homeostasis and insulin sensitivity. Turning them on in liver or fat is sufficient to impair glucose homeostasis. Caveolin-1, a protein involved in regulation of insulin signalling, is a direct target gene of the miRNAs. These findings show that these miRNAs regulate insulin sensitivity and identify a new potential target for the treatment of type 2 diabetes and obesity.

Date: 2011
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DOI: 10.1038/nature10112

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