SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

Nadine Laguette (), Bijan Sobhian, Nicoletta Casartelli, Mathieu Ringeard, Christine Chable-Bessia, Emmanuel Ségéral, Ahmad Yatim, Stéphane Emiliani, Olivier Schwartz and Monsef Benkirane ()
Additional contact information
Nadine Laguette: Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France
Bijan Sobhian: Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France
Nicoletta Casartelli: Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
Mathieu Ringeard: Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France
Christine Chable-Bessia: Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France
Emmanuel Ségéral: Institut Cochin, Université Paris Descartes, CNRS UMR 8104 INSERM U567, Paris, France
Ahmad Yatim: Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France
Stéphane Emiliani: Institut Cochin, Université Paris Descartes, CNRS UMR 8104 INSERM U567, Paris, France
Olivier Schwartz: Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
Monsef Benkirane: Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS UPR1142, Montpellier 34000 France

Nature, 2011, vol. 474, issue 7353, 654-657

Abstract: How macrophages avoid HIV-1 infection HIV-1 is unable to replicate efficiently in dendritic cells, the antigen-presenting tissue cells that function in both innate and adaptive immunity. Other primate lentiviruses, including HIV-2 and some simian immunodeficiency viruses, express a protein called Vpx that is able to overcome the block to replication. Two groups now report the identification of the restriction factor in dendritic cells and macrophages that is overcome by Vpx. Vpx is found to induce degradation of the protein SAMHD1. Mutations in SAMHD1 cause Aicardi–Goutières syndrome, a disorder characterized by inappropriate activation of the immune system. Knockdown of SAMHD1 increases HIV-1 replication in dendritic cells, which could be important for generating appropriate immune responses to the virus.

Date: 2011
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature10117 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:474:y:2011:i:7353:d:10.1038_nature10117

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10117

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().