XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast

E. L. van Dijk, C. L. Chen, Y. d’Aubenton-Carafa, S. Gourvennec, M. Kwapisz, V. Roche, C. Bertrand, M. Silvain, P. Legoix-Né, S. Loeillet, A. Nicolas, C. Thermes () and A. Morillon ()
Additional contact information
E. L. van Dijk: Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France
C. L. Chen: Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France
Y. d’Aubenton-Carafa: Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France
S. Gourvennec: ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
M. Kwapisz: ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
V. Roche: ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
C. Bertrand: ncRNA, epigenetic and genome fluidity, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
M. Silvain: Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France
P. Legoix-Né: NGS Platform, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
S. Loeillet: Recombination and Genome instability, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
A. Nicolas: Recombination and Genome instability, Institut Curie, Centre de recherche, CNRS UMR3244, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
C. Thermes: Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France
A. Morillon: Centre de Génétique Moléculaire (CNRS UPR 3404), avenue de la Terrasse, 91198 Gif sur Yvette, France

Nature, 2011, vol. 475, issue 7354, 114-117

Abstract: Antisense control by ncRNAs Several lines of evidence suggest that non-coding RNAs (ncRNAs) have a significant role in gene regulation in eukaryotes. Genome-wide deep sequencing in the yeast Saccharomyces cerevisiae has now identified antisense ncRNAs that are destabilized by the Xrn1 RNA exonuclease in the 5′ RNA-decay pathway. These Xrn1-sensitive unstable transcripts, or XUTs, seem to function in gene repression and can be antagonized by histone H3K4 trimethylation.

Date: 2011
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DOI: 10.1038/nature10118

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