Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

Robert M. Anthony, Toshihiko Kobayashi, Fredrik Wermeling and Jeffrey V. Ravetch ()
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Robert M. Anthony: Laboratory of Molecular Genetics and Immunology, The Rockefeller University
Toshihiko Kobayashi: Laboratory of Molecular Genetics and Immunology, The Rockefeller University
Fredrik Wermeling: Laboratory of Molecular Genetics and Immunology, The Rockefeller University
Jeffrey V. Ravetch: Laboratory of Molecular Genetics and Immunology, The Rockefeller University

Nature, 2011, vol. 475, issue 7354, 110-113

Abstract: Anti-inflammatory action by DC-SIGN High-dose intravenous immunoglobulin is used to suppress autoantibody-mediated inflammation in various clinical settings. A study in 'humanized' mice shows that the lectin receptor DC-SIGN initiates this response through an anti-inflammatory cascade induced by a natural ligand — sialylated IgG crystallized fragment — the levels of which are regulated by inflammation. This pathway induces the production of the TH2 cytokines interleukin-33 and interleukin-4 and is a possible therapeutic target for autoimmune diseases.

Date: 2011
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DOI: 10.1038/nature10134

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