Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Andrea Facciabene, Xiaohui Peng, Ian S. Hagemann, Klara Balint, Andrea Barchetti, Li-Ping Wang, Phyllis A. Gimotty, C. Blake Gilks, Priti Lal, Lin Zhang and George Coukos ()
Additional contact information
Andrea Facciabene: Ovarian Cancer Research Center, University of Pennsylvania
Xiaohui Peng: Ovarian Cancer Research Center, University of Pennsylvania
Ian S. Hagemann: University of Pennsylvania
Klara Balint: Ovarian Cancer Research Center, University of Pennsylvania
Andrea Barchetti: Ovarian Cancer Research Center, University of Pennsylvania
Li-Ping Wang: University of Pennsylvania
Phyllis A. Gimotty: University of Pennsylvania
C. Blake Gilks: University of British Columbia, Vancouver
Priti Lal: University of Pennsylvania
Lin Zhang: Ovarian Cancer Research Center, University of Pennsylvania
George Coukos: Ovarian Cancer Research Center, University of Pennsylvania

Nature, 2011, vol. 475, issue 7355, 226-230

Abstract: Immune tolerance and angiogenesis in tumour growth Regulatory T (Treg) cells are an important immunosuppressive lymphocyte population implicated in peripheral tolerance and in the pathogenesis of autoimmunity and cancer. The mechanisms accounting for Treg cell accumulation in tumours, and the precise mechanisms through which Treg cells contribute to tumour progression, are not fully understood. Facciabene et al. show that the chemokine CCL28 recruits Treg cells to hypoxic tumours, where they secrete VEGF-A and contribute to tumour angiogenesis. These findings suggest that tumour immune tolerance and angiogenesis are closely linked and may act together in promoting tumour growth.

Date: 2011
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DOI: 10.1038/nature10169

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