Low-energy control of electrical turbulence in the heart

Stefan Luther (), Flavio H. Fenton (), Bruce G. Kornreich, Amgad Squires, Philip Bittihn, Daniel Hornung, Markus Zabel, James Flanders, Andrea Gladuli, Luis Campoy, Elizabeth M. Cherry, Gisa Luther, Gerd Hasenfuss, Valentin I. Krinsky, Alain Pumir, Robert F. Gilmour and Eberhard Bodenschatz
Additional contact information
Stefan Luther: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Flavio H. Fenton: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Bruce G. Kornreich: Cornell University
Amgad Squires: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Philip Bittihn: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Daniel Hornung: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Markus Zabel: Heart Research Center Göttingen (HRCG), Robert-Koch-Strasse 40
James Flanders: Cornell University
Andrea Gladuli: Cornell University
Luis Campoy: Cornell University
Elizabeth M. Cherry: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Gisa Luther: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Gerd Hasenfuss: Heart Research Center Göttingen (HRCG), Robert-Koch-Strasse 40
Valentin I. Krinsky: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17
Alain Pumir: Laboratoire de Physique de l’Ecole Normale Supérieure de Lyon, Université Lyon 1 and CNRS
Robert F. Gilmour: Cornell University
Eberhard Bodenschatz: Max Planck Institute for Dynamics and Self-Organization, Am Fassberg 17

Nature, 2011, vol. 475, issue 7355, 235-239

Abstract: Towards safer heart resuscitation Cardiac defibrillation is usually achieved using a single high-energy electric shock of up to 4,000 volts, which can be damaging to the heart tissue. Eberhard Bodenschatz and colleagues show how the disordered electrical dynamics that underlie cardiac fibrillation can be controlled using low-energy electrical pulses. They show, in tests on dogs, that intrinsic homogeneities in the cardiac tissue (such as the vasculature) serve as nucleation sites for the generation of waves of electrical activity that can target the instabilities and bring the tissue dynamics back into synchrony. The new technique, called low-energy antifibrillation pacing or LEAP, delivers five sequential low-energy electrical field pulses to the fibrillating heart — an average energy reduction of 84% compared to standard defibrillation.

Date: 2011
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DOI: 10.1038/nature10216

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