Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

Sayaka Sekiya and Atsushi Suzuki ()
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Sayaka Sekiya: Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku
Atsushi Suzuki: Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku

Nature, 2011, vol. 475, issue 7356, 390-393

Abstract: Direct routes to liver-like cells Two groups report new approaches that could lead to the generation of hepatocyte-like cells for liver engineering and regenerative medicine. Lijian Hui and colleagues use a combination of Gata4, Hnf1a and Foxa3 overexpression and p19Arf inactivation to convert mouse fibroblasts directly into induced hepatic (iHep) cells that have gene-expression profiles close to that of mature hepatocytes. Sayaka Sekiya and Atsushi Suzuki identify three combinations of two transcription factors, comprising Hnf4a plus Foxa1, Foxa2 or Foxa3, that can convert mouse embryonic and adult fibroblasts directly into functional iHep cells. Both groups show that when iHep cells are transplanted into mice with a gene deficiency that models liver injury, the cells are able to repopulate the livers and restore their function.

Date: 2011
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DOI: 10.1038/nature10263

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