Dynamic molecular processes mediate cellular mechanotransduction

Brenton D. Hoffman, Carsten Grashoff and Martin A. Schwartz ()
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Brenton D. Hoffman: Robert M. Berne Cardiovascular Research Center, University of Virginia
Carsten Grashoff: Robert M. Berne Cardiovascular Research Center, University of Virginia
Martin A. Schwartz: Robert M. Berne Cardiovascular Research Center, University of Virginia

Nature, 2011, vol. 475, issue 7356, 316-323

Abstract: Abstract Cellular responses to mechanical forces are crucial in embryonic development and adult physiology, and are involved in numerous diseases, including atherosclerosis, hypertension, osteoporosis, muscular dystrophy, myopathies and cancer. These responses are mediated by load-bearing subcellular structures, such as the plasma membrane, cell-adhesion complexes and the cytoskeleton. Recent work has demonstrated that these structures are dynamic, undergoing assembly, disassembly and movement, even when ostensibly stable. An emerging insight is that transduction of forces into biochemical signals occurs within the context of these processes. This framework helps to explain how forces of varying strengths or dynamic characteristics regulate distinct signalling pathways.

Date: 2011
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DOI: 10.1038/nature10316

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