Nuclear export dynamics of RNA–protein complexes

David Grünwald, Robert H. Singer () and Michael Rout
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David Grünwald: Delft University of Technology, Faculty of Applied Sciences, Kavli Institute of NanoScience, 2628 CJ Delft, The Netherlands.
Robert H. Singer: Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine
Michael Rout: The Rockefeller University

Nature, 2011, vol. 475, issue 7356, 333-341

Abstract: Abstract The central dogma of molecular biology — DNA makes RNA makes proteins — is a flow of information that in eukaryotes encounters a physical barrier: the nuclear envelope, which encapsulates, organizes and protects the genome. Nuclear-pore complexes, embedded in the nuclear envelope, regulate the passage of molecules to and from the nucleus, including the poorly understood process of the export of RNAs from the nucleus. Recent imaging approaches focusing on single molecules have provided unexpected insight into this crucial step in the information flow. This review addresses the latest studies of RNA export and presents some models for how this complex process may work.

Date: 2011
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DOI: 10.1038/nature10318

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