Transforming binding affinities from three dimensions to two with application to cadherin clustering

Yinghao Wu, Jeremie Vendome, Lawrence Shapiro, Avinoam Ben-Shaul () and Barry Honig ()
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Yinghao Wu: Columbia University
Jeremie Vendome: Columbia University
Lawrence Shapiro: Columbia University
Avinoam Ben-Shaul: Institute of Chemistry and the Fritz Haber Research Center, The Hebrew University
Barry Honig: Columbia University

Nature, 2011, vol. 475, issue 7357, 510-513

Abstract: Interactions on the cell surface Relating the strengths of interactions occurring in two dimensions on membrane surfaces to those measured in three dimensions in solution is a perennial problem in cell biology. Barry Honig and colleagues use a computational and theoretical approach that enables a new type of structurally- and biophysically-driven analysis of processes that occur on cell surfaces. Applying this approach to cadherin-mediated cell adhesion reveals novel principles about how cell–cell interactions drive receptor clustering on membrane surfaces.

Date: 2011
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DOI: 10.1038/nature10183

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