Functional mapping of single spines in cortical neurons in vivo

Xiaowei Chen, Ulrich Leischner, Nathalie L. Rochefort, Israel Nelken and Arthur Konnerth ()
Additional contact information
Xiaowei Chen: Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
Ulrich Leischner: Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
Nathalie L. Rochefort: Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
Israel Nelken: Silberman Institute of Life Sciences and the Edmond and Lily Safra Center for Brain Sciences, Hebrew University, Jerusalem 91904, Israel
Arthur Konnerth: Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany

Nature, 2011, vol. 475, issue 7357, 501-505

Abstract: Mapping neural connectivity in the brain It is notoriously difficult to determine how individual neurons integrate the inputs from the many incoming dendritic signals in live animals. Arthur Konnerth and colleagues use a new variant of the two-photon imaging technique to visualize sound-evoked activity in the spines of cortical neurons at single-synapse resolution in vivo. They find that individual spines are highly tuned for specific tones and that even neighbouring spines on the same dendrite can be tuned to different frequencies. This work establishes a new method for the mapping of functionally defined single synapses in the living brain.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/nature10193 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:475:y:2011:i:7357:d:10.1038_nature10193

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10193

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().