Oxysterols direct B-cell migration through EBI2

Changlu Liu (), Xia V. Yang, Jiejun Wu, Chester Kuei, Neelakandha S. Mani, Li Zhang, Jingxue Yu, Steven W. Sutton, Ning Qin, Homayon Banie, Lars Karlsson, Siquan Sun and Timothy W. Lovenberg
Additional contact information
Changlu Liu: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Xia V. Yang: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Jiejun Wu: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Chester Kuei: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Neelakandha S. Mani: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Li Zhang: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Jingxue Yu: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Steven W. Sutton: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Ning Qin: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Homayon Banie: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Lars Karlsson: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Siquan Sun: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row
Timothy W. Lovenberg: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row

Nature, 2011, vol. 475, issue 7357, 519-523

Abstract: EBI2 receptors revealed as oxysterols The EBI2 receptor (Epstein–Barr virus-induced gene 2, also known as GPR183) was recently shown to be linked to autoimmune disease, and is a critical regulator of the humoral immune response. It is a G-protein-coupled receptor, and its natural ligand has been unknown. Two groups now bring an end to the 'orphan' status of this receptor with identification of specific oxysterols as its natural ligands. The most potent ligand and activator is 7a,25-dihydroxycholesterol, and the EBI2–oxysterol signalling pathway has an important role in the adaptive immune response.

Date: 2011
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DOI: 10.1038/nature10226

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