Control of TH17 cells occurs in the small intestine

Enric Esplugues (), Samuel Huber, Nicola Gagliani, Anja E. Hauser, Terrence Town, Yisong Y. Wan, William O’Connor, Anthony Rongvaux, Nico Van Rooijen, Ann M. Haberman, Yoichiro Iwakura, Vijay K. Kuchroo, Jay K. Kolls, Jeffrey A. Bluestone, Kevan C. Herold and Richard A. Flavell ()
Additional contact information
Enric Esplugues: Yale University School of Medicine
Samuel Huber: Yale University School of Medicine
Nicola Gagliani: San Raffaele Diabetes Research Institute (HSR-DRI)
Anja E. Hauser: German Rheumatism Research Center (DRFZ), A Leibniz Institute
Terrence Town: Cedars-Sinai Medical Center
Yisong Y. Wan: Lineberger Comprehensive Cancer Center, The University of North Carolina, School of Medicine
William O’Connor: Yale University School of Medicine
Anthony Rongvaux: Yale University School of Medicine
Nico Van Rooijen: Faculty of Medicine, Vrije Universiteit
Ann M. Haberman: Yale University School of Medicine
Yoichiro Iwakura: Center for Experimental Medicine, Institute of Medical Science, University of Tokyo
Vijay K. Kuchroo: Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
Jay K. Kolls: LSU Health Sciences Center
Jeffrey A. Bluestone: Diabetes Center at the University of California San Francisco
Kevan C. Herold: Yale University School of Medicine
Richard A. Flavell: Yale University School of Medicine

Nature, 2011, vol. 475, issue 7357, 514-518

Abstract: Keeping TH17 cells under wraps Interleukin-17-producing T helper (TH17) cells serve an important role in the immune system, but are strongly implicated in the pathogenesis of numerous autoimmune diseases including rheumatoid arthritis and multiple sclerosis. How the immune system controls TH17 cells in vivo remains unclear. Using mice in which tolerance was induced by CD3-specific antibody, a model of sepsis and influenza A viral infection, Esplugues et al. demonstrate that TH17 cells are kept in check by redirecting the cells to the small intestine where they are eliminated or re-programmed to acquire immunosuppressive and regulatory properties. This work identifies the gastrointestinal tract as a site for control of TH17 cells.

Date: 2011
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DOI: 10.1038/nature10228

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