Oxysterols direct immune cell migration via EBI2

Sébastien Hannedouche, Juan Zhang, Tangsheng Yi, Weijun Shen, Deborah Nguyen, João P. Pereira, Danilo Guerini, Birgit U. Baumgarten, Silvio Roggo, Ben Wen, Richard Knochenmuss, Sophie Noël, Francois Gessier, Lisa M. Kelly, Mirka Vanek, Stephane Laurent, Inga Preuss, Charlotte Miault, Isabelle Christen, Ratna Karuna, Wei Li, Dong-In Koo, Thomas Suply, Christian Schmedt, Eric C. Peters, Rocco Falchetto, Andreas Katopodis, Carsten Spanka, Marie-Odile Roy, Michel Detheux, Yu Alice Chen, Peter G. Schultz, Charles Y. Cho, Klaus Seuwen, Jason G. Cyster and Andreas W. Sailer ()
Additional contact information
Sébastien Hannedouche: Euroscreen S.A.
Juan Zhang: Analytical Sciences, Novartis Institutes for BioMedical Research
Tangsheng Yi: University of California San Francisco
Weijun Shen: Genomics Institute of the Novartis Research Foundation
Deborah Nguyen: Genomics Institute of the Novartis Research Foundation
João P. Pereira: University of California San Francisco
Danilo Guerini: Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research
Birgit U. Baumgarten: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research
Silvio Roggo: Global Discovery Chemistry, Novartis Institutes for BioMedical Research
Ben Wen: Genomics Institute of the Novartis Research Foundation
Richard Knochenmuss: Analytical Sciences, Novartis Institutes for BioMedical Research
Sophie Noël: Euroscreen S.A.
Francois Gessier: Global Discovery Chemistry, Novartis Institutes for BioMedical Research
Lisa M. Kelly: University of California San Francisco
Mirka Vanek: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research
Stephane Laurent: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research
Inga Preuss: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research
Charlotte Miault: Global Discovery Chemistry, Novartis Institutes for BioMedical Research
Isabelle Christen: Analytical Sciences, Novartis Institutes for BioMedical Research
Ratna Karuna: Analytical Sciences, Novartis Institutes for BioMedical Research
Wei Li: Genomics Institute of the Novartis Research Foundation
Dong-In Koo: The Scripps Research Institute
Thomas Suply: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research
Christian Schmedt: Genomics Institute of the Novartis Research Foundation
Eric C. Peters: Genomics Institute of the Novartis Research Foundation
Rocco Falchetto: Analytical Sciences, Novartis Institutes for BioMedical Research
Andreas Katopodis: Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research
Carsten Spanka: Global Discovery Chemistry, Novartis Institutes for BioMedical Research
Marie-Odile Roy: Euroscreen S.A.
Michel Detheux: Euroscreen S.A.
Yu Alice Chen: Genomics Institute of the Novartis Research Foundation
Peter G. Schultz: Genomics Institute of the Novartis Research Foundation
Charles Y. Cho: Genomics Institute of the Novartis Research Foundation
Klaus Seuwen: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research
Jason G. Cyster: University of California San Francisco
Andreas W. Sailer: Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research

Nature, 2011, vol. 475, issue 7357, 524-527

Abstract: EBI2 receptors revealed as oxysterols The EBI2 receptor (Epstein–Barr virus-induced gene 2, also known as GPR183) was recently shown to be linked to autoimmune disease, and is a critical regulator of the humoral immune response. It is a G-protein-coupled receptor, and its natural ligand has been unknown. Two groups now bring an end to the 'orphan' status of this receptor with identification of specific oxysterols as its natural ligands. The most potent ligand and activator is 7a,25-dihydroxycholesterol, and the EBI2–oxysterol signalling pathway has an important role in the adaptive immune response.

Date: 2011
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DOI: 10.1038/nature10280

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