Legionella pneumophila SidD is a deAMPylase that modifies Rab1

Yunhao Tan and Zhao-Qing Luo ()
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Yunhao Tan: Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA
Zhao-Qing Luo: Purdue University, 915 West State Street, West Lafayette, Indiana 47907, USA

Nature, 2011, vol. 475, issue 7357, 506-509

Abstract: A pathogen's protein armoury Legionella pneumophila secretes multiple effectors into host cells during infection, some of which modify host trafficking and thereby aid intracellular replication. One of these modifications is AMPylation of Rab1 by L. pneumophila SidM. This study adds another layer to this regulation by demonstrating that a second L. pneumophila effector, SidD, deAMPylates Rab1. The identification of SidD suggests that this pathogen uses a specific set of proteins to hijack the activity of Rab1 for its own purposes.

Date: 2011
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DOI: 10.1038/nature10307

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