Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs

S.-K. Chen, T. C. Badea () and S. Hattar ()
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S.-K. Chen: Johns Hopkins University
T. C. Badea: Retinal Circuit Development & Genetics Unit, N-NRL/NEI/NIH
S. Hattar: Johns Hopkins University

Nature, 2011, vol. 476, issue 7358, 92-95

Abstract: Variation in the third retinal photoreceptor For many years, it was thought that rods and cones were the only light-detecting cells in the mammalian retina, but about 20 years ago a third photoreceptor was identified, the intrinsically photosensitive retinal ganglion cells (ipRGCs). Expressing the photo-pigment melanopsin, these cells assist in the regulation of circadian photoentrainment and help to drive the pupillary light reflex. Chen et al. now show that these two functions are associated with distinct subpopulations of ipRGCs, defined by specific molecular factors and acting in parallel.

Date: 2011
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DOI: 10.1038/nature10206

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