A continuum model for tumour suppression

Alice H. Berger, Alfred G. Knudson and Pier Paolo Pandolfi ()
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Alice H. Berger: Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School
Alfred G. Knudson: Fox Chase Cancer Center
Pier Paolo Pandolfi: Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School

Nature, 2011, vol. 476, issue 7359, 163-169

Abstract: Tumour suppression modelled The 'two-hit' hypothesis of tumorigenesis, originally proposed in 1971 by Alfred Knudson using retinoblastoma as a model, explained the role of recessive tumour suppressor genes (TSGs) in dominantly inherited cancer-susceptibility syndromes, in which tumorigenesis was later shown to require two mutations, one in each copy of a single tumour suppressor gene. Four decades later, it is clear that even partial inactivation of tumour suppressors can critically contribute to tumorigenesis. This Review by Alice Berger, Alfred Knudson and Pier Paolo Pandolfi proposes a continuum model of TSG function to explain the full range of TSG mutations found in cancer.

Date: 2011
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DOI: 10.1038/nature10275

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