A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Diego De Stefani, Anna Raffaello, Enrico Teardo, Ildikò Szabò and Rosario Rizzuto ()
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Diego De Stefani: University of Padua, 35121 Padua, Italy
Anna Raffaello: University of Padua, 35121 Padua, Italy
Enrico Teardo: University of Padua, 35121 Padua, Italy
Ildikò Szabò: University of Padua, 35121 Padua, Italy
Rosario Rizzuto: University of Padua, 35121 Padua, Italy

Nature, 2011, vol. 476, issue 7360, 336-340

Abstract: Mitochondrial Ca2+ channel identified Central to the role of the mitochondrion in cellular metabolism is its ability to control the fluxes of the key signalling ion, Ca2+. This is done by a highly selective ion channel known as the mitochondrial calcium uniporter. The molecular nature of this channel has remained elusive, but now two groups report the identification of a 40-kilodalton protein in the inner membrane of mitochondria as the active channel of the uniporter. This protein contains two transmembrane domains and exhibits calcium-channel activity in vitro and in vivo.

Date: 2011
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DOI: 10.1038/nature10230

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