Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Joshua M. Baughman, Fabiana Perocchi, Hany S. Girgis, Molly Plovanich, Casey A. Belcher-Timme, Yasemin Sancak, X. Robert Bao, Laura Strittmatter, Olga Goldberger, Roman L. Bogorad, Victor Koteliansky and Vamsi K. Mootha ()
Additional contact information
Joshua M. Baughman: Harvard Medical School and Massachusetts General Hospital
Fabiana Perocchi: Harvard Medical School and Massachusetts General Hospital
Hany S. Girgis: Harvard Medical School and Massachusetts General Hospital
Molly Plovanich: Harvard Medical School and Massachusetts General Hospital
Casey A. Belcher-Timme: Harvard Medical School and Massachusetts General Hospital
Yasemin Sancak: Harvard Medical School and Massachusetts General Hospital
X. Robert Bao: Harvard Medical School and Massachusetts General Hospital
Laura Strittmatter: Harvard Medical School and Massachusetts General Hospital
Olga Goldberger: Harvard Medical School and Massachusetts General Hospital
Roman L. Bogorad: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Victor Koteliansky: Alnylam Pharmaceuticals, Inc.
Vamsi K. Mootha: Harvard Medical School and Massachusetts General Hospital

Nature, 2011, vol. 476, issue 7360, 341-345

Abstract: Mitochondrial Ca2+ channel identified Central to the role of the mitochondrion in cellular metabolism is its ability to control the fluxes of the key signalling ion, Ca2+. This is done by a highly selective ion channel known as the mitochondrial calcium uniporter. The molecular nature of this channel has remained elusive, but now two groups report the identification of a 40-kilodalton protein in the inner membrane of mitochondria as the active channel of the uniporter. This protein contains two transmembrane domains and exhibits calcium-channel activity in vitro and in vivo.

Date: 2011
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DOI: 10.1038/nature10234

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