Different substrate-dependent transition states in the active site of the ribosome

Stephan Kuhlenkoetter, Wolfgang Wintermeyer and Marina V. Rodnina ()
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Stephan Kuhlenkoetter: Max Planck Institute for Biophysical Chemistry, Am Fassberg 11
Wolfgang Wintermeyer: Max Planck Institute for Biophysical Chemistry, Am Fassberg 11
Marina V. Rodnina: Max Planck Institute for Biophysical Chemistry, Am Fassberg 11

Nature, 2011, vol. 476, issue 7360, 351-354

Abstract: Transition states in ribosome active site Two reactions occur in the ribosome catalytic centre: peptide bond formation and peptide release. Previous modelling has suggested that the hydrolysis reaction during release involves a concerted proton shuttle in the transition state. Kuhlenkoetter et al. have conducted proton inventories of the reaction and find that one hydrogen bond is formed during the rate-limiting step, rather than the three produced during peptide bond formation. They conclude that the peptidyl transferase centre is able to support two different transition states.

Date: 2011
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DOI: 10.1038/nature10247

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