Engineered reversal of the β-oxidation cycle for the synthesis of fuels and chemicals

Clementina Dellomonaco, James M. Clomburg, Elliot N. Miller and Ramon Gonzalez ()
Additional contact information
Clementina Dellomonaco: Rice University
James M. Clomburg: Rice University
Elliot N. Miller: Rice University
Ramon Gonzalez: Rice University

Nature, 2011, vol. 476, issue 7360, 355-359

Abstract: Reversing the route to biofuels Biosynthetic pathways that mediate the formation of amino acids, fatty acids and secondary metabolites can be re-engineered to produce complex compounds that show promise as potential biofuels. Dellomonaco et al. show that reversing the direction of the endogenous β-oxidation cycle of fatty acids in Escherichia coli can be used to efficiently synthesize alcohols and carboxylic acids — both potential biofuels — with various chain lengths and functionalities. The β-oxidation cycle is ubiquitous in microbes, so it should be possible to engineer the combinatorial synthesis of non-native products in industrial organisms without recruiting foreign genes.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature10333 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:476:y:2011:i:7360:d:10.1038_nature10333

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10333

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().