Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Ryan D. Morin, Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, Tesa M. Severson, Readman Chiu, Matthew Field, Shaun Jackman, Martin Krzywinski, David W. Scott, Diane L. Trinh, Jessica Tamura-Wells, Sa Li, Marlo R. Firme, Sanja Rogic, Malachi Griffith, Susanna Chan, Oleksandr Yakovenko, Irmtraud M. Meyer, Eric Y. Zhao, Duane Smailus, Michelle Moksa, Suganthi Chittaranjan, Lisa Rimsza, Angela Brooks-Wilson, John J. Spinelli, Susana Ben-Neriah, Barbara Meissner, Bruce Woolcock, Merrill Boyle, Helen McDonald, Angela Tam, Yongjun Zhao, Allen Delaney, Thomas Zeng, Kane Tse, Yaron Butterfield, Inanç Birol, Rob Holt, Jacqueline Schein, Douglas E. Horsman, Richard Moore, Steven J. M. Jones, Joseph M. Connors, Martin Hirst, Randy D. Gascoyne and Marco A. Marra ()
Additional contact information
Ryan D. Morin: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Maria Mendez-Lago: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Andrew J. Mungall: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Rodrigo Goya: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Karen L. Mungall: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Richard D. Corbett: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Nathalie A. Johnson: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Tesa M. Severson: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Readman Chiu: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Matthew Field: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Shaun Jackman: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Martin Krzywinski: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
David W. Scott: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Diane L. Trinh: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Jessica Tamura-Wells: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Sa Li: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Marlo R. Firme: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Sanja Rogic: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Malachi Griffith: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Susanna Chan: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Oleksandr Yakovenko: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Irmtraud M. Meyer: Centre for High-throughput Biology, Vancouver
Eric Y. Zhao: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Duane Smailus: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Michelle Moksa: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Suganthi Chittaranjan: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Lisa Rimsza: University of Arizona
Angela Brooks-Wilson: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
John J. Spinelli: Cancer Control Research, BC Cancer Agency, Vancouver
Susana Ben-Neriah: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Barbara Meissner: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Bruce Woolcock: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Merrill Boyle: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Helen McDonald: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Angela Tam: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Yongjun Zhao: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Allen Delaney: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Thomas Zeng: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Kane Tse: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Yaron Butterfield: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Inanç Birol: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Rob Holt: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Jacqueline Schein: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Douglas E. Horsman: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Richard Moore: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Steven J. M. Jones: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Joseph M. Connors: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Martin Hirst: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver
Randy D. Gascoyne: Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver
Marco A. Marra: Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver

Nature, 2011, vol. 476, issue 7360, 298-303

Abstract: Abstract Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature10351 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:476:y:2011:i:7360:d:10.1038_nature10351

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10351

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().