Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

Jakub Sedzinski, Maté Biro, Annelie Oswald, Jean-Yves Tinevez, Guillaume Salbreux and Ewa Paluch ()
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Jakub Sedzinski: Max Planck Institute of Molecular Cell Biology and Genetics
Maté Biro: Max Planck Institute of Molecular Cell Biology and Genetics
Annelie Oswald: Max Planck Institute of Molecular Cell Biology and Genetics
Jean-Yves Tinevez: Max Planck Institute of Molecular Cell Biology and Genetics
Guillaume Salbreux: Max Planck Institute for the Physics of Complex Systems
Ewa Paluch: Max Planck Institute of Molecular Cell Biology and Genetics

Nature, 2011, vol. 476, issue 7361, 462-466

Abstract: How dividing cells stay in shape Studies of the mechanism of cytokinesis, the process by which a mother cell undergoes cleavage to form two separated daughter cells, often focus on the action of the contractile actomyosin ring at the cell equator. Ewa Paluch and colleagues instead investigate the mechanics of the actomyosin cortex found at the cell poles during cytokinesis. They find that the presence of a contractile polar cortex makes cytokinesis an inherently unstable process that can result in misalignment of the constriction ring. They propose that the membrane blebs forming at the poles of dividing cells stabilize the position by releasing cortical contractility. These findings reveal an inherent instability in the shape of a dividing cell and demonstrate a novel mechanism that helps to limit shape instability.

Date: 2011
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DOI: 10.1038/nature10286

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