A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation

Vlad C. Seitan, Bingtao Hao, Kikuë Tachibana-Konwalski, Thais Lavagnolli, Hegias Mira-Bontenbal, Karen E. Brown, Grace Teng, Tom Carroll, Anna Terry, Katie Horan, Hendrik Marks, David J. Adams, David G. Schatz, Luis Aragon, Amanda G. Fisher, Michael S. Krangel (), Kim Nasmyth () and Matthias Merkenschlager ()
Additional contact information
Vlad C. Seitan: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
Bingtao Hao: Duke University Medical Center
Kikuë Tachibana-Konwalski: University of Oxford
Thais Lavagnolli: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
Hegias Mira-Bontenbal: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
Karen E. Brown: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
Grace Teng: Yale University School of Medicine
Tom Carroll: Epigenetics Section, MRC Clinical Sciences Centre, Imperial College London
Anna Terry: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
Katie Horan: Central Biological Services, Imperial College London
Hendrik Marks: Nijmegen Center for Molecular Life Sciences, Radboud University
David J. Adams: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
David G. Schatz: Yale University School of Medicine
Luis Aragon: Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London
Amanda G. Fisher: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London
Michael S. Krangel: Duke University Medical Center
Kim Nasmyth: University of Oxford
Matthias Merkenschlager: Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London

Nature, 2011, vol. 476, issue 7361, 467-471

Abstract: Cohesin role in T-cell differentiation Cohesin is well known as the protein complex that holds sister chromatids together after replication so that they are not prematurely separated before mitosis. More recent data suggested that cohesin also has a cell-division-independent function, the loss of which can lead to disease. Matthias Merkenschlager and colleagues report that in mouse thymocytes, cohesin is required for long-range interactions that underlie several events leading to T-cell receptor rearrangement and thymocyte differentiation.

Date: 2011
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DOI: 10.1038/nature10312

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