Protection of repetitive DNA borders from self-induced meiotic instability

Gerben Vader, Hannah G. Blitzblau, Mihoko A. Tame, Jill E. Falk, Lisa Curtin and Andreas Hochwagen ()
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Gerben Vader: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Hannah G. Blitzblau: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Mihoko A. Tame: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Jill E. Falk: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Lisa Curtin: Whitehead Institute for Biomedical Research, 9 Cambridge Center
Andreas Hochwagen: Whitehead Institute for Biomedical Research, 9 Cambridge Center

Nature, 2011, vol. 477, issue 7362, 115-119

Abstract: Preventing DNA injury in meiosis Breakages in repetitive ribosomal DNA (rDNA) sequences can lead to rearrangements through non-allelic homologous recombination, a common source of genomic instability and human disease. Programmed breaks are an essential event in meiosis, however. Vader et al. have identified two proteins, Pch2 and Orc1, that protect the repetitive rDNA array from inappropriate breakages. Surprisingly, Sir2, which establishes the protective heterochromatin environment at rDNA, also makes the border between this heterochromatin and the neighbouring euchromatin susceptible to breaks. Such junctions are therefore at high risk for non-allelic homologous recombination in meiosis.

Date: 2011
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DOI: 10.1038/nature10331

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