Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

Alex Sigal, Jocelyn T. Kim, Alejandro B. Balazs, Erez Dekel, Avi Mayo, Ron Milo and David Baltimore ()
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Alex Sigal: California Institute of Technology
Jocelyn T. Kim: California Institute of Technology
Alejandro B. Balazs: California Institute of Technology
Erez Dekel: Weizmann Institute of Science
Avi Mayo: Weizmann Institute of Science
Ron Milo: Weizmann Institute of Science
David Baltimore: California Institute of Technology

Nature, 2011, vol. 477, issue 7362, 95-98

Abstract: HIV persists through continued transmission Antiretroviral therapy suppresses, but does not eradicate, HIV infection. Low-level viraemia continues for life because of the persistence of treatment-resistant reservoirs of the virus. Various different types of reservoir are thought to exist. David Baltimore and colleagues use a combination of mathematical modelling and a cell culture model of HIV infection and drug treatment to propose that ongoing HIV replication can occur in the presence of drugs if the cells become infected through cell-to-cell transmission. They propose that cell-to-cell spread of virus could be a source of localized and intermittent ongoing replication, which may show little evolution, and which could contribute to replenishment of the virus reservoir and virus persistence.

Date: 2011
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DOI: 10.1038/nature10347

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