The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Saul A. Villeda, Jian Luo, Kira I. Mosher, Bende Zou, Markus Britschgi, Gregor Bieri, Trisha M. Stan, Nina Fainberg, Zhaoqing Ding, Alexander Eggel, Kurt M. Lucin, Eva Czirr, Jeong-Soo Park, Sebastien Couillard-Després, Ludwig Aigner, Ge Li, Elaine R. Peskind, Jeffrey A. Kaye, Joseph F. Quinn, Douglas R. Galasko, Xinmin S. Xie, Thomas A. Rando and Tony Wyss-Coray ()
Additional contact information
Saul A. Villeda: Stanford University School of Medicine
Jian Luo: Stanford University School of Medicine
Kira I. Mosher: Stanford University School of Medicine
Bende Zou: AfaSci Research Laboratory
Markus Britschgi: Stanford University School of Medicine
Gregor Bieri: Stanford University School of Medicine
Trisha M. Stan: Stanford University School of Medicine
Nina Fainberg: Stanford University School of Medicine
Zhaoqing Ding: Stanford University School of Medicine
Alexander Eggel: Stanford University School of Medicine
Kurt M. Lucin: Stanford University School of Medicine
Eva Czirr: Stanford University School of Medicine
Jeong-Soo Park: Stanford University School of Medicine
Sebastien Couillard-Després: Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21
Ludwig Aigner: Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Strubergasse 21
Ge Li: University of Washington School of Medicine
Elaine R. Peskind: University of Washington School of Medicine
Jeffrey A. Kaye: Layton Aging and Alzheimer's Disease Center, Oregon Health and Science University, CR131, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201-3098, USA; and Portland VA Medical Center
Joseph F. Quinn: Layton Aging and Alzheimer's Disease Center, Oregon Health and Science University, CR131, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201-3098, USA; and Portland VA Medical Center
Douglas R. Galasko: University of California San Diego, 9500 Gilman Drive 0948
Xinmin S. Xie: AfaSci Research Laboratory
Thomas A. Rando: Stanford University School of Medicine
Tony Wyss-Coray: Stanford University School of Medicine

Nature, 2011, vol. 477, issue 7362, 90-94

Abstract: Blood-borne factors affect the ageing brain Regenerative capacity and cognitive function decline during ageing. A study using heterochronic parabiosis, in which pairs of young and old mice are surgically joined by a shared blood supply, shows that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in ageing mice. A proteomic screen identified a subset of plasma signalling proteins that correlate with the decreased neurogenesis observed in both normal ageing and parabiosis. CCL11 (also known as eotoxin) and β2-microglobulin — factors classically involved in immune responses — were among the identified factors able to decrease progenitor frequency and neural differentiation.

Date: 2011
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DOI: 10.1038/nature10357

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