Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans

Caroline J. Breitbach, James Burke, Derek Jonker, Joe Stephenson, Andrew R. Haas, Laura Q. M. Chow, Jorge Nieva, Tae-Ho Hwang, Anne Moon, Richard Patt, Adina Pelusio, Fabrice Le Boeuf, Joe Burns, Laura Evgin, Naomi De Silva, Sara Cvancic, Terri Robertson, Ji-Eun Je, Yeon-Sook Lee, Kelley Parato, Jean-Simon Diallo, Aaron Fenster, Manijeh Daneshmand, John C. Bell and David H. Kirn ()
Additional contact information
Caroline J. Breitbach: Jennerex Inc., 450 Sansome Street, 16th floor
James Burke: 801 North 29th Street, Billings Clinic
Derek Jonker: Ottawa Hospital Research Institute, 501 Smyth Road
Joe Stephenson: Cancer Centers of the Carolinas, 3 Butternut Drive
Andrew R. Haas: University of Pennsylvania Medical Center, 3400 Spruce Street
Laura Q. M. Chow: Ottawa Hospital Research Institute, 501 Smyth Road
Jorge Nieva: 801 North 29th Street, Billings Clinic
Tae-Ho Hwang: Pusan National University, Jangjeon-dong GeumJeong-gu
Anne Moon: Jennerex Inc., 450 Sansome Street, 16th floor
Richard Patt: RadMD, 712 Hyde Park
Adina Pelusio: Jennerex Inc., 450 Sansome Street, 16th floor
Fabrice Le Boeuf: Ottawa Hospital Research Institute, 501 Smyth Road
Joe Burns: Ottawa Hospital Research Institute, 501 Smyth Road
Laura Evgin: Ottawa Hospital Research Institute, 501 Smyth Road
Naomi De Silva: Ottawa Hospital Research Institute, 501 Smyth Road
Sara Cvancic: Ottawa Hospital Research Institute, 501 Smyth Road
Terri Robertson: Jennerex Inc., 450 Sansome Street, 16th floor
Ji-Eun Je: Pusan National University, Jangjeon-dong GeumJeong-gu
Yeon-Sook Lee: Pusan National University, Jangjeon-dong GeumJeong-gu
Kelley Parato: Ottawa Hospital Research Institute, 501 Smyth Road
Jean-Simon Diallo: Ottawa Hospital Research Institute, 501 Smyth Road
Aaron Fenster: Robarts Research Institute, 100 Perth Drive, P.O. Box 5015
Manijeh Daneshmand: Ottawa Hospital Research Institute, 501 Smyth Road
John C. Bell: Ottawa Hospital Research Institute, 501 Smyth Road
David H. Kirn: Jennerex Inc., 450 Sansome Street, 16th floor

Nature, 2011, vol. 477, issue 7362, 99-102

Abstract: Oncolytic viruses as cancer therapy Oncolytic viruses, either natural or engineered, preferentially infect and lyse tumour cells. David Kirn and colleagues now report a phase I clinical trial in which they demonstrate systemic delivery of the engineered oncolytic virus JX-594 selectively to tumour tissue after a single injection. Tumour biopsies indicate that the virus replicates in cancer but not in adjacent normal tissue. JX-594 is engineered to replicate in a broad spectrum of cancer cells harbouring activation of the epidermal growth factor receptor/Ras pathway. Although the trial was not designed to demonstrate clinical efficacy, the results suggest that JX-594 may elicit a clinical response in some patients.

Date: 2011
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DOI: 10.1038/nature10358

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