TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

Mark C. Siracusa, Steven A. Saenz, David A. Hill, Brian S. Kim, Mark B. Headley, Travis A. Doering, E. John Wherry, Heidi K. Jessup, Lori A. Siegel, Taku Kambayashi, Emily C. Dudek, Masato Kubo, Antonella Cianferoni, Jonathan M. Spergel, Steven F. Ziegler, Michael R. Comeau and David Artis ()
Additional contact information
Mark C. Siracusa: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Steven A. Saenz: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
David A. Hill: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Brian S. Kim: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Mark B. Headley: Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, University of Washington School of Medicine
Travis A. Doering: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
E. John Wherry: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Heidi K. Jessup: Inflammation Research, Amgen Inc.
Lori A. Siegel: Inflammation Research, Amgen Inc.
Taku Kambayashi: Perelman School of Medicine, University of Pennsylvania
Emily C. Dudek: Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania
Masato Kubo: Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute
Antonella Cianferoni: Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania
Jonathan M. Spergel: Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania
Steven F. Ziegler: Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, University of Washington School of Medicine
Michael R. Comeau: Inflammation Research, Amgen Inc.
David Artis: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania

Nature, 2011, vol. 477, issue 7363, 229-233

Abstract: TSLP's role in allergy The cytokine thymic stromal lymphopoietin (TSLP) has been described as the master switch of allergic inflammation. Here, TSLP is shown to induce the development of basophils from bone-marrow progenitors and to activate peripheral basophils in an interleukin-3 (IL-3)-independent manner. Basophils elicited by TSLP differ from those dependent on IL-3 both phenotypically and functionally, and may play an important part in allergic diseases associated with T-helper type 2 cells.

Date: 2011
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DOI: 10.1038/nature10329

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