Different patterns of peripheral migration by memory CD4+ and CD8+ T cells

Thomas Gebhardt (), Paul G. Whitney, Ali Zaid, Laura K. Mackay, Andrew G. Brooks, William R. Heath, Francis R. Carbone and Scott N. Mueller ()
Additional contact information
Thomas Gebhardt: The University of Melbourne
Paul G. Whitney: The University of Melbourne
Ali Zaid: The University of Melbourne
Laura K. Mackay: The University of Melbourne
Andrew G. Brooks: The University of Melbourne
William R. Heath: The University of Melbourne
Francis R. Carbone: The University of Melbourne
Scott N. Mueller: The University of Melbourne

Nature, 2011, vol. 477, issue 7363, 216-219

Abstract: T-cell migration is subset-specific T cells are crucial to immunity at surface tissues such as skin, which represent entry points for many infectious agents. Migration and targeting to these specific regions is thought to be a key to efficient immune protection. Gebhardt et al. provide evidence for differential migration of helper and killer T-cell subsets after local skin infection with herpes simplex virus, with helper and killer memory T cells segregating to dermis and epidermis respectively. CD4+ T cells, through their ability to access the circulation, are thought to be responsible for providing protection distal to the primary site of infection.

Date: 2011
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DOI: 10.1038/nature10339

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