Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

Daeho Park, Claudia Z. Han, Michael R. Elliott, Jason M. Kinchen, Paul C. Trampont, Soumita Das, Sheila Collins, Jeffrey J. Lysiak, Kyle L. Hoehn and Kodi S. Ravichandran ()
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Daeho Park: Center for Cell Clearance, University of Virginia
Claudia Z. Han: Center for Cell Clearance, University of Virginia
Michael R. Elliott: Center for Cell Clearance, University of Virginia
Jason M. Kinchen: Center for Cell Clearance, University of Virginia
Paul C. Trampont: Center for Cell Clearance, University of Virginia
Soumita Das: University of Virginia
Sheila Collins: Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute
Jeffrey J. Lysiak: University of Virginia
Kyle L. Hoehn: University of Virginia
Kodi S. Ravichandran: Center for Cell Clearance, University of Virginia

Nature, 2011, vol. 477, issue 7363, 220-224

Abstract: How phagocytes keep their appetite When a phagocyte engulfs a dying cell, it essentially doubles its cellular contents, yet phagocytes are capable of ingesting several apoptotic cells one after the other. The factors regulating this impressive engulfment capacity are not well understood. Kodi Ravichandran and colleagues show here that the mitochondrial membrane protein Ucp2, which is known to be linked to metabolic diseases and atherosclerosis, is critically important to engulfment capacity.

Date: 2011
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DOI: 10.1038/nature10340

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