Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

Marceline Côté, John Misasi, Tao Ren, Anna Bruchez, Kyungae Lee, Claire Marie Filone, Lisa Hensley, Qi Li, Daniel Ory, Kartik Chandran and James Cunningham ()
Additional contact information
Marceline Côté: Brigham and Women’s Hospital
John Misasi: Brigham and Women’s Hospital
Tao Ren: New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, Harvard Medical School
Anna Bruchez: Brigham and Women’s Hospital
Kyungae Lee: New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, Harvard Medical School
Claire Marie Filone: Brigham and Women’s Hospital
Lisa Hensley: United States Army Medical Research Institute of Infectious Diseases
Qi Li: Brigham and Women’s Hospital
Daniel Ory: Diabetic Cardiovascular Disease Center, Washington University School of Medicine
Kartik Chandran: Brigham and Women’s Hospital
James Cunningham: Brigham and Women’s Hospital

Nature, 2011, vol. 477, issue 7364, 344-348

Abstract: Filovirus infectivity factors The extraordinary virulence of the Ebola and Marburg filoviruses has spurred intensive research into the molecular mechanisms by which they multiply and cause disease. Carette et al. use a genome-wide genetic screen in human cells to identify factors required for entry of Ebola virus. The screen uncovered 67 mutations disrupting all six members of the homotypic fusion and vacuole protein-sorting (HOPS) multisubunit tethering complex, which is involved in the fusion of endosomes to lysosomes, and 39 independent mutations that disrupt the endo/lysosomal cholesterol transporter protein Niemann–Pick C1 (NPC1). Côté et al. report the identification of a novel benzylpiperazine adamantane diamide-derived compound that inhibits EboV infection in cell culture, with NPC1 being the target. The unexpected role for the hereditary disease gene NPC1 in Ebola virus infection may facilitate the development of antifilovirus therapeutics.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature10380 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:477:y:2011:i:7364:d:10.1038_nature10380

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10380

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().