Mouse genomic variation and its effect on phenotypes and gene regulation

Thomas M. Keane, Leo Goodstadt, Petr Danecek, Michael A. White, Kim Wong, Binnaz Yalcin, Andreas Heger, Avigail Agam, Guy Slater, Martin Goodson, Nicholas A. Furlotte, Eleazar Eskin, Christoffer Nellåker, Helen Whitley, James Cleak, Deborah Janowitz, Polinka Hernandez-Pliego, Andrew Edwards, T. Grant Belgard, Peter L. Oliver, Rebecca E. McIntyre, Amarjit Bhomra, Jérôme Nicod, Xiangchao Gan, Wei Yuan, Louise van der Weyden, Charles A. Steward, Sendu Bala, Jim Stalker, Richard Mott, Richard Durbin, Ian J. Jackson, Anne Czechanski, José Afonso Guerra-Assunção, Leah Rae Donahue, Laura G. Reinholdt, Bret A. Payseur, Chris P. Ponting, Ewan Birney, Jonathan Flint () and David J. Adams ()
Additional contact information
Thomas M. Keane: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Leo Goodstadt: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Petr Danecek: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Michael A. White: Laboratory of Genetics, University of Wisconsin
Kim Wong: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Binnaz Yalcin: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Andreas Heger: MRC Functional Genomics Unit, Anatomy and Genetics, University of Oxford
Avigail Agam: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Guy Slater: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Martin Goodson: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Nicholas A. Furlotte: University of California
Eleazar Eskin: University of California
Christoffer Nellåker: MRC Functional Genomics Unit, Anatomy and Genetics, University of Oxford
Helen Whitley: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
James Cleak: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Deborah Janowitz: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Polinka Hernandez-Pliego: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Andrew Edwards: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
T. Grant Belgard: MRC Functional Genomics Unit, Anatomy and Genetics, University of Oxford
Peter L. Oliver: MRC Functional Genomics Unit, Anatomy and Genetics, University of Oxford
Rebecca E. McIntyre: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Amarjit Bhomra: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Jérôme Nicod: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Xiangchao Gan: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Wei Yuan: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Louise van der Weyden: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Charles A. Steward: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Sendu Bala: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Jim Stalker: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Richard Mott: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Richard Durbin: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Ian J. Jackson: Medical Research Council Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, UK
Anne Czechanski: The Jackson Laboratory
José Afonso Guerra-Assunção: European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
Leah Rae Donahue: The Jackson Laboratory
Laura G. Reinholdt: The Jackson Laboratory
Bret A. Payseur: Laboratory of Genetics, University of Wisconsin
Chris P. Ponting: MRC Functional Genomics Unit, Anatomy and Genetics, University of Oxford
Ewan Birney: European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
Jonathan Flint: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
David J. Adams: The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK

Nature, 2011, vol. 477, issue 7364, 289-294

Abstract: Abstract We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that the molecular nature of functional variants and their position relative to genes vary according to the effect size of the locus. These sequences provide a starting point for a new era in the functional analysis of a key model organism.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (14)

Downloads: (external link)
https://www.nature.com/articles/nature10413 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:477:y:2011:i:7364:d:10.1038_nature10413

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10413

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().