Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Camilla Burnett, Sara Valentini, Filipe Cabreiro, Martin Goss, Milán Somogyvári, Matthew D. Piper, Matthew Hoddinott, George L. Sutphin, Vid Leko, Joshua J. McElwee, Rafael P. Vazquez-Manrique, Anne-Marie Orfila, Daniel Ackerman, Catherine Au, Giovanna Vinti, Michèle Riesen, Ken Howard, Christian Neri, Antonio Bedalov, Matt Kaeberlein, Csaba Sőti, Linda Partridge and David Gems ()
Additional contact information
Camilla Burnett: Evolution and Environment, University College London
Sara Valentini: Evolution and Environment, University College London
Filipe Cabreiro: Evolution and Environment, University College London
Martin Goss: Evolution and Environment, University College London
Milán Somogyvári: Semmelweis University
Matthew D. Piper: Evolution and Environment, University College London
Matthew Hoddinott: Evolution and Environment, University College London
George L. Sutphin: University of Washington
Vid Leko: Fred Hutchinson Cancer Research Center
Joshua J. McElwee: Evolution and Environment, University College London
Rafael P. Vazquez-Manrique: Inserm, Unit 894, Laboratory of Neuronal Cell Biology and Pathology
Anne-Marie Orfila: Inserm, Unit 894, Laboratory of Neuronal Cell Biology and Pathology
Daniel Ackerman: Evolution and Environment, University College London
Catherine Au: Evolution and Environment, University College London
Giovanna Vinti: Evolution and Environment, University College London
Michèle Riesen: Evolution and Environment, University College London
Ken Howard: MRC Laboratory for Molecular Cell Biology, University College London
Christian Neri: Inserm, Unit 894, Laboratory of Neuronal Cell Biology and Pathology
Antonio Bedalov: Fred Hutchinson Cancer Research Center
Matt Kaeberlein: University of Washington
Csaba Sőti: Semmelweis University
Linda Partridge: Evolution and Environment, University College London
David Gems: Evolution and Environment, University College London

Nature, 2011, vol. 477, issue 7365, 482-485

Abstract: Sirtuin activity revisited Overexpression of sirtuins has been reported to increase lifespan in Caenorhabditis elegans and Drosophila melanogaster. The effects of dietary restriction on the lifespan of flies have also been reported to be Sir2-dependent. Here it is shown that these findings are attributable to the confounding effects of genetic background. This work suggests that the life-extending effect of sirtuin overexpression may be limited to yeast, and also supports studies in yeast and C. elegans that show that the effects of dietary restriction are not mediated by sirtuins.

Date: 2011
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DOI: 10.1038/nature10296

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