Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA

Leo Kurian, R. Palanimurugan, Daniela Gödderz and R. Jürgen Dohmen ()
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Leo Kurian: Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a
R. Palanimurugan: Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a
Daniela Gödderz: Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a
R. Jürgen Dohmen: Institute for Genetics, University of Cologne, Cologne Biocenter, Zülpicher Strasse 47a

Nature, 2011, vol. 477, issue 7365, 490-494

Abstract: Polyamines give antizyme the slip Ornithine decarboxylase (ODC), the rate-limiting enzyme in the biosynthesis of polyamines, is regulated by an antizyme (OAZ). Polyamines induce antizyme expression by promoting ribosomal frame-shifting within the OAZ messenger RNA (mRNA). Although it was presumed that the polyamines interacted with either the fully transcribed mRNA or the ribosome itself, Kurian et al. have found that the regulation occurs through the interaction of polyamines with the nascent OAZ polypeptide, to inhibit ribosome stalling and promote its translation.

Date: 2011
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DOI: 10.1038/nature10393

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