Structures of the RNA-guided surveillance complex from a bacterial immune system

Blake Wiedenheft, Gabriel C. Lander, Kaihong Zhou, Matthijs M. Jore, Stan J. J. Brouns, John van der Oost, Jennifer A. Doudna () and Eva Nogales ()
Additional contact information
Blake Wiedenheft: Howard Hughes Medical Institute, University of California
Gabriel C. Lander: Lawrence Berkeley National Laboratory
Kaihong Zhou: Howard Hughes Medical Institute, University of California
Matthijs M. Jore: Laboratory of Microbiology, Wageningen University, Dreijenplein 10
Stan J. J. Brouns: Laboratory of Microbiology, Wageningen University, Dreijenplein 10
John van der Oost: Laboratory of Microbiology, Wageningen University, Dreijenplein 10
Jennifer A. Doudna: Howard Hughes Medical Institute, University of California
Eva Nogales: Howard Hughes Medical Institute, University of California

Nature, 2011, vol. 477, issue 7365, 486-489

Abstract: Key player in bacterial immunity Bacterial cells use CRISPRs (clustered regularly interspaced short palindromic repeats) to defend against invading phages. The central catalytic component in this process is Cascade, a 12-subunit complex consisting of proteins and RNA. The structure of Cascade, free and bound to target RNA, has now been solved by cryoelectron microscopy and three-dimensional reconstruction. These structures show the changes in architecture that are induced by target binding, and will assist future studies addressing how these conformational changes affect restriction of the phage.

Date: 2011
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DOI: 10.1038/nature10402

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