Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

Mohan Viswanathan and Leonard Guarente ()
Additional contact information
Mohan Viswanathan: Massachusetts Institute of Technology
Leonard Guarente: Massachusetts Institute of Technology

Nature, 2011, vol. 477, issue 7365, E1-E2

Abstract: Abstract Arising from H. A. Tissenbaum & L. Guarente Nature 410, 227–230 (2001)10.1038/35065638 Tissenbaum and Guarente1 identified the first metazoan Sir2 homologue shown to affect lifespan, Caenorhabditis elegans sir-2.1. Independent transgenic lines harbouring extrachromosomal DNA arrays containing sir-2.1 and the dominant transgene marker rol-6(su1006) were reported to extend mean lifespan between 15% and 50%1. Similar extensions in mean lifespan were also found for lines in which the sir-2.1 transgenic arrays were integrated into the genome following γ-irradiation1. However, the extension of lifespan was overestimated in a high-copy sir-2.1 transgene-containing worm strain because of an unlinked mutation.

Date: 2011
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature10440 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:477:y:2011:i:7365:d:10.1038_nature10440

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature10440

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().