The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Yue Zhao, Jieling Yang, Jianjin Shi, Yi-Nan Gong, Qiuhe Lu, Hao Xu, Liping Liu and Feng Shao ()
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Yue Zhao: Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College
Jieling Yang: Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College
Jianjin Shi: National Institute of Biological Sciences
Yi-Nan Gong: National Institute of Biological Sciences
Qiuhe Lu: National Institute of Biological Sciences
Hao Xu: National Institute of Biological Sciences
Liping Liu: National Institute of Biological Sciences
Feng Shao: National Institute of Biological Sciences

Nature, 2011, vol. 477, issue 7366, 596-600

Abstract: Pathogen specificity in innate immunity The inflammasomes are multiprotein complexes involved in innate immunity, and induce an immune response to pathogenic microbes by activating the caspase 1 protease. Two groups now report that the intracellular receptors known as NAIPs (NLR family, apoptosis inhibitory proteins), previously thought to have an auxiliary role in recognizing microbial proteins, are in fact central to the process. Eric Kofoed and Russell Vance, and Feng Shao and colleagues, show that different members of the NAIP family bind to different bacterial ligands, including bacterial flagellin and a conserved bacterial type III secretion system rod protein.

Date: 2011
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DOI: 10.1038/nature10510

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