Dynamics of human adipose lipid turnover in health and metabolic disease

Peter Arner (), Samuel Bernard, Mehran Salehpour, Göran Possnert, Jakob Liebl, Peter Steier, Bruce A. Buchholz, Mats Eriksson, Erik Arner, Hans Hauner, Thomas Skurk, Mikael Rydén, Keith N. Frayn and Kirsty L. Spalding ()
Additional contact information
Peter Arner: Karolinska University Hospital
Samuel Bernard: Institut Camille Jordan, CNRS UMR 5208, University of Lyon
Mehran Salehpour: Ion Physics, Uppsala University
Göran Possnert: Ion Physics, Uppsala University
Jakob Liebl: Faculty of Physics – Isotope Research, University of Vienna
Peter Steier: Faculty of Physics – Isotope Research, University of Vienna
Bruce A. Buchholz: Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, 7000 East Ave., L-397
Mats Eriksson: Karolinska University Hospital
Erik Arner: Karolinska University Hospital
Hans Hauner: Else Kröner-Fresenius Centre for Nutritional Medicine, Technische Universität Münich
Thomas Skurk: Else Kröner-Fresenius Centre for Nutritional Medicine, Technische Universität Münich
Mikael Rydén: Karolinska University Hospital
Keith N. Frayn: Oxford Centre for Diabetes, Endocrinology & Metabolism, Churchill Hospital
Kirsty L. Spalding: Karolinska Institute, SE-171 77

Nature, 2011, vol. 478, issue 7367, 110-113

Abstract: Long-term lipid turnover in adipose tissue Lipid turnover is an important factor in determining how adipose tissue stores and releases energy in humans. By measuring carbon-14, derived from nuclear bomb tests, in the fat-cell lipids of a large cohort of individuals, Arner et al. estimate lipid turnover over a prolonged period in sickness and in health. The data show that during the ten-year lifespan of a typical human adipocyte, its triglyceride content is renewed six times. Unusual lipid turnover patterns correlate to conditions with disturbed lipid metabolism, suggesting it as a potential target for the treatment of metabolic disease.

Date: 2011
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DOI: 10.1038/nature10426

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