A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

Hua Tian, Brian Biehs, Søren Warming, Kevin G. Leong, Linda Rangell, Ophir D. Klein () and Frederic J. de Sauvage ()
Additional contact information
Hua Tian: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Brian Biehs: Institute for Human Genetics and Program in Craniofacial and Mesenchymal Biology, UCSF, 513 Parnassus Avenue, San Francisco, California 94143-0442, USA
Søren Warming: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Kevin G. Leong: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Linda Rangell: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ophir D. Klein: Institute for Human Genetics and Program in Craniofacial and Mesenchymal Biology, UCSF, 513 Parnassus Avenue, San Francisco, California 94143-0442, USA
Frederic J. de Sauvage: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2011, vol. 478, issue 7368, 255-259

Abstract: Stem cells held in reserve Two main epithelial stem-cell pools have been previously identified in the small intestine epithelium, but the relative functions of these two pools and their interrelationship are not well understood. Using genetic lineage tracing and lineage ablation studies in mice, Frederic de Sauvage and colleagues have now found that Lgr5-expressing cells are dispensable for normal intestinal homeostasis — the renewal of the epithelium every few days. In the absence of these cells, Bmi1-expressing cells act as a reserve stem-cell pool and replenish the active Lgr5-expressing stem cells.

Date: 2011
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DOI: 10.1038/nature10408

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