Peripheral education of the immune system by colonic commensal microbiota

Stephanie K. Lathrop, Seth M. Bloom, Sindhuja M. Rao, Katherine Nutsch, Chan-Wang Lio, Nicole Santacruz, Daniel A. Peterson, Thaddeus S. Stappenbeck and Chyi-Song Hsieh ()
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Stephanie K. Lathrop: Washington University School of Medicine
Seth M. Bloom: Washington University School of Medicine
Sindhuja M. Rao: Washington University School of Medicine
Katherine Nutsch: Washington University School of Medicine
Chan-Wang Lio: Washington University School of Medicine
Nicole Santacruz: Washington University School of Medicine
Daniel A. Peterson: University of Nebraska-Lincoln
Thaddeus S. Stappenbeck: Washington University School of Medicine
Chyi-Song Hsieh: Washington University School of Medicine

Nature, 2011, vol. 478, issue 7368, 250-254

Abstract: Learning to tolerate friendly bacteria Understanding how the immune system becomes tolerant to foreign antigens from commensal bacteria is a fundamental question, as breakdown of tolerance can result in unwanted responses such as inflammatory bowel disease. It has been suggested that tolerogenic regulatory T (Treg) cells are generated in response to commensal bacteria, but there is little direct evidence to support this hypothesis. A study of the colonic T-cell antigen receptor repertoire of mice now shows that microbial antigens direct the generation of antigen-specific inducible Treg cells in the colon. Commensal-induced Treg cells seem to maintain mucosal tolerance and protect mice from colitis.

Date: 2011
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DOI: 10.1038/nature10434

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